
Mom's Hand and Mom's Dead Hand are a reference to Wallmasters from The Legend of Zelda. Death's Head was likely inspired by Bubbles from The Legend of Zelda on the NES, as they are both skulls that are invulnerable and maneuver by bouncing off walls. Pin, The Frail, Scolex, Needle, and Pasty may have all been inspired by Lanmola from The Legend of Zelda: A Link To The Past. The original flash version of The Binding of Isaac uses a HUD that is a nearly direct port of the original NES Zelda title's HUD. Coins, Keys, and Bombs are used similarly to Rupees, Keys, and Bombs in the NES game. The general gameplay is a reference to the original NES title, right down to the HUD. 'M - Reference to a glitch in Pokemon: Red and Blue.
TMTRAINER - Reference to a glitch in Pokemon: Red and Blue.Poke Go - Reference to the mobile game Pokémon Go.Friendly Ball - The item is a reference to Poké Balls from the Pokémon franchise.Mega Mush - Reference to the Mega Mushroom power-up.Mini Mush - Reference to the Mini Mushroom power-up.Magic Mushroom - Reference to the Super Mushroom power-up.Liberty Cap - Touch fuzzy, get dizzy (Reference to level 1-7 in the Super Nintendo title Yoshi's Island).
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How to Jump - The cover looks like the NES Super Mario Bros. Gnawed Leaf - The item's appearance is a reference to the Leaf power-up, the effect to the Tanooki suit power-up from the series. Bobby-Bomb - Reference to the Bob-omb enemy from the Mario series. The Gamekid - A reference to the Nintendo Gameboy, with its effect referencing Pac-Man. Lil Spewer - A smaller version of the protagonist from the original game. Triachnid - The protagonist of the original game.
Steven - The protagonist of the original game. Steven - Attaches a small head to Isaac, similar to that of the smaller Steven. Little Steven - The smaller steven attached to Steven. Sisters Vis - A boss taken from the original game.
Little Gish - A familiar based off of the protagonist (and boss respectively.).Gish - The protagonist of the original game.Clot - Enemies that appear to be smaller versions of Gish.Ball of Tar - Gives Isaac an appearance similar to that of Gish.The presumed offspring of the Larries from the original game. Little Horn - Shares the same name as a boss from the game.Brownie - Shares the same name as a boss from the game.SMB Super Fan - Gives Isaac an appearance similar to Super Meat Boy.shrinking after his defeat in Super Meat Boy. Fetus, Epic Fetus - Reference to the main antagonist from the game. Ball of Bandages - Becomes Bandage Girl.